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These findings of "less is sometimes more," broadly consistent with the notion of "neural efficiency," were evident in the earliest functional studies of intelligence [36], and have subsequently been supported in both intelligence [37] and creativity neuroimaging studies [38].
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Earlier functional studies proposed that these vessels were used to store and serve food and drink in commensal contexts.
The tetramer-based studies of allogeneic SCT recipients confirm earlier functional studies in that CMV-specific T cells present in the graft have a protective effect against recurrent CMV antigenemia and CMV disease.
Interestingly, early functional studies showed an inhibitory effect of pseudokinase domain on the kinase domain of JAK2 [9], [9].
This finding is consistent with the results of earlier functional studies on T14 bioactivity [27] [28] and indicates that T30 similarly exerts its effects acutely through an allosteric mechanism.
Despite the grouping of amine neuron populations in earlier functional studies, it is becoming increasingly clear that at a small subset or individual neuron level, considerable specificity exists in the fields of innervation of amine neurons and in their function.
Early functional studies in X. euvesicatoria have shown that several ncRNA contribute to pathogenicity [ 38, 39].
Early functional studies of PDE4 showed that specific inhibition with rolipram leads to inhibition of the spontaneous contraction of myometrial strips [ 34, 35].
Early functional studies from Tlsty's group and others suggested that the CDK4/6 inhibitor p16ink4a could be a particularly important factor in suppressing the progression of DCIS [ 44- 46].
Early functional studies have demonstrated a role for miRNAs in apoptosis/proliferation [ 23, 24], development [ 25- 27], insulin secretion [ 28] and cholesterol metabolism [ 29, 30] whilst differential expression studies have shown a possible role in multiple cancers [ 31, 32].
These data are in agreement with the results from earlier functional studies of individual genes like PHE1, AGL23, AGL61, AGL62 and AGL80 and propose a role for Type I MADS-box genes in female gametophyte and endosperm development.
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