In early lesions, Tp53 mutation, as detected by IHC positivity and confirmed by laser capture microdissection sequencing, precedes the earliest foci of AKT hyperphosphorylation, and these foci seem to give rise to the larger PIN lesions with progression to invasive carcinomas.
China, India, and the Ottoman Empire are the early focus of the study, which draws on biology, anthropology, economics, and political philosophy to explain the evolution.
Despite a course change, Mr. Fine said he is not entirely abandoning the earlier focus of his company, which he founded with Marc Altheim in 1995.
The early focus of those second-phase talks will be on a transitional program to cover the period immediately after March 2019 when Britain is to quit the bloc.
It served as an early focus of national unification and as a crossroads for Western Eastern European and European Western Asian trade.
An early focus of the interrogation, they said, has been anything he knows about the guerrilla war, in hopes of quickly gleaning information that might help prevent attacks and disrupt or dismember cells responsible for the attacks.
Briefly, it seems as though Markovits himself wants us to re-open the case - but in fact the early focus of the novel turns out to be on Pattieson.
The early focus of this concern was British fans, but the development of the anti-hooligan architecture of football grounds around the world points to the international scope of the problem.
Whereas the early focus of the project was getting state and campaign officials up to speed on the range and severity of cybersecurity threats, now the work centers on training officials to become self-sufficient in defending themselves.
