However, the tolerability of gemcitabine was several fold better following dosing during the late light to early dark span (7 15 HALO) as compared to late darkness to early light (19 3 HALO).
During the early dark ages, however, there were no stars (and certainly no planets or people).
It is a huge space in a city of small spaces; growers arrive in the early, dark hours of the morning with dahlias and marigolds by the bucketful.
Hours later, this last interaction in particular was still hovering around me like smoke as I drove home through the too-early dark.
Aside from some early dark brooding paintings from around this time, her paintings of pregnant women, mothers and children are among her most emotionally disturbing.
Instead, we travelled east through prosperous but not lordly streets, past brick and mock-Tudor houses with their lights on in the early dark and their Christmas lights already blinking out of the snowcapped shrubbery.
Among those headed for the exit was a genuine hero of the flood, an officer who had held the department together during those early dark days with his own wet hands.
My school was in the middle of a housing estate on the west coast of Scotland, and you'd hear shouts outside, dogs barking, as the lights of the classroom burned in the early dark.
I then exceeded the free parking time (of two hours) by an hour and 20 minutes and, due to it being still very early, dark and still wet, I left without paying the extra parking.
We found significant reductions in rapid eye movement sleep (REMS) during the light phase in both females and males, and significant increases in numbers of vigilance state transitions during the early dark phase in females but not in males.
