Alternatively, correlation of longer duration to pathology may result from regions being the earliest affected and therefore exposed to accumulating pathology over periods of time.
Gpr52 is enriched in the D2 neurons (Komatsu et al., 2014), which are amongst the earliest affected in HD (Raymond et al., 2011), possibly reflecting their susceptibility to mHtt due to expression of Gpr52.
The astroglial atrophy preceded the appearance of senile plaques and appeared first (as early as 1-month-old animals) in the entorhinal cortex, the region earliest affected by the AD pathology.
The 4 cheetahs recovered completely under veterinary care, and a convalescent-phase sample, which tested negative by PCR and virus isolation, was available for only 1 of the 2 earliest affected cheetahs (animal B).
HNPGLs occur in 75% carriers of paternally inherited mutations, starting from relatively young age (earliest affected aged 22 years) and often multifocal but are not malignant (Kunst et al. 2011).
Second, Gpr52 has been recently characterized as a Gαs-coupled receptor highly enriched in the striatum, especially D2 neurons (Sawzdargo et al., 1999; Komatsu et al., 2014), which are amongst the earliest affected in HD (Raymond et al., 2011).
