Southward dispersals in an earlier time frame from the NW region and in a later time frame from the SE region were inferred.
However, differences in experimental design and analyses complicate the comparison to previous studies, especially since we focused on an earlier time frame.
This issue may be ameliorated by using different types of response options, such as time to complete an activity, or comparing abilities in an earlier time frame, such as over a five-year span.
Strengths of this study include the use of responses recorded by participants at separate time points, meaning the health and drinking status at an earlier time frame is not subject to problems with retrospective recall.
Most importantly, the moderate trauma-related increase of PCT and the rapidly declining concentrations provide a baseline value near to the normal range at an earlier time frame than for CRP, thus allowing a faster and more valid prediction of sepsis during the early period after trauma.
The findings that CTCs are detected even in early-stage non-metastatic cancer patients indicate that tumor dissemination occurs in a much earlier time frame than previously thought, directly challenging the long-standing paradigm that metastatic initiation is a later event in tumorigenesis.
Although our study represents a modern time period, the earlier time frame used by Kasenda et al (2000-03) allowed for a longer median follow-up of 11.6 (range 8.8-12.6) years, compared with our shorter median period of 4.9 years with a minimum time of 2.7 years. 3 A longer period, which accounts for studies with long follow-up times, may have further increased the publication rate in our study.
For this purpose, an ROI defining the heart content was generated by thresholding the averaged early time frames which visualized the blood flow through the heart.
Perfusion-like images from early time frames of PET imaging are more suitable for image co-registration with morphological MRI [6, 7].
