Earlier studies gave conflicting information about why: maybe the heart muscle cells were proliferating too little, or maybe too much.
It will be important to discuss why behaviors under FR3/0.66s protocol in this study and FR4/0.5s protocol in earlier study give rise to very different behavioral patterns.
I think it is very important for the authors to emphasize this comparison and discuss why behaviors under FR3/0.66s protocol in this study and FR4/0.5s protocol in earlier study give rise to very different behavior patterns.
Early studies gave (i) Meridional distribution as shown in Fig. 1c; and (ii) Land and marine breakdown as shown in Fig. 1b. .
The two earliest studies gave plasmoquine plus quinine every three weeks for three rounds (Kligler 1931 PSE) and atebrin plus plasmochin once only (Simeons 1938 IND).
This study was designed to investigate cognitive abilities and their correlations with CTG repeat expansion size in classical Myotonic dystrophy type 1 (DM1), given that earlier studies have indicated cognitive deficits, possibly correlating with blood CTG repeats expansion size.
In our earlier studies, tirapazamine given before radiotherapy was able to reduce subsequent metastases formation, whereas RB6145 showed little effect (Lunt et al, 2005).
However, early clinical studies gave conflicting findings, with some suggesting a similar outcome to that of the conventional Charnley stem, while others suggested a worse outcome (Kalairajah et al. 2004, Makela et al. 2008).
According to earlier studies women giving birth by caesarean section on maternal request are more often older and born outside of Sweden.
More trials or a meta-analysis with individual patient data from earlier studies might give better answers to the question on the long-term effect.
