The MammoSite™ applicator has been associated with early side effects comparable with traditional breast conserving therapy.
In clinical practice, corticosteroids have been administered to reduce the early side effects of the anti-venom.
We analysed retrospectively the early side effects and the response rate in the first patients, who received a therapy with Lu-PSMA in our departments.
In this study, we analysed retrospectively the early side effects and the response rate in the first patients, who received a therapy with 177Lu-DKFZ-617 PSMA (Lu-PSMA), in our departments as the last possible option [18].
Early side effects according to CTC v2.0 depended on the irradiated anatomical regions [ 18].
Early side effects, i.e. alopecia, fatigue or headache, were scored with the CTC-AE 3.0 scoring system.
PAR-1 inhibitors decreased intensity of acute, immediate-early side effects (enteritis), but did not affect late-onset side effects [ 243– 243].
Early side effects on the skin might be considered an indicator of clinical radiation sensitivity, and their intensity, score, and distribution have been previously described [9].
Early side effects included mainly grade 4 haematologic toxicity (neutropaenia in 79% of patients, thrombocytopaenia in 69%, anaemia in 22%), grade 4 stomatitis (19%), and four early deaths (7% of patients), at least partially related to toxicity.
5 14 They must also consider possible early side effects of combined HRT such as breast tenderness, vaginal discharge, and uterine bleeding, which usually resolve with time or dose titration.
An incident user design also helps to ensure that the analysis captures all events that occurred after the start of treatment and reduces the chance of bias that could otherwise occur from patients who stop treatments as a result of early side effects.
