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Furthermore, it is suggested that the mutation of the metastatic phenotype is lower at earlier recurrence sites.
Patients with a high expression level of HDAC2 or HDAC3 were prone to earlier recurrence of HCC according to Kaplan-Meier estimates (Table 1, Figure 1B).
Using the Kaplan-Meier test, and including the patients with historic HBV infection (n = 22), the patients in cluster 2 were found to have significantly (P = 0.0006) earlier recurrence time (mean, 7.6 months) than the other patients (mean, 57.6 mo) (Figure 6B, Table S10), whereas individual miR-21 or miR-122 could not predict patients' survival nor cancer recurrence after surgery (data not shown).
The presence of bone marrow micrometastases was related to earlier recurrence.
This is highly unlikely, since low XIAP mRNA is a marker for earlier recurrence in cervical cancer patients [ 25].
More accurate prediction of treatment failure would facilitate earlier recurrence detection and maximize the therapeutic effects of salvage treatment.
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It is unclear whether the overexpression of TYMS contributed to these earlier recurrences.
Patients lacking these receptors tend to have shorter disease free survival and earlier recurrences than those expressing these receptors [ 6].
Early recurrence and rapid rise after surgery have been linked to increased death rates.
Conclusions: The risk of early recurrence for node positive patients is dependent on menopausal status.
Svensson, C. et al. REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancer.
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