As previously mentioned, we wished to avoid the lack of blinding to earlier responses inherent in the use of written pain diaries.
It is possible that the ability to metastasize is not a late acquisition of a cancer as previously thought, but an early and inherent genetic property of breast cancer that may be detected at diagnosis of the primary tumour.
Moreover, the prognostic power of the 70-gene profile indicates that the ability to metastasise to distant sites is an early and inherent genetic property of breast cancer, which argues against the widely accepted idea that metastatic potential is acquired relatively late during multistep tumorigenesis (Bernards and Weinberg, 2002).
As television learned early, there is inherent drama in medicine: the human body at war against alien invaders or even against itself, doctors marshaling the forces of modern science and technology to combat disease and save lives.
Early marriage is inherent in this community.
Moreover, as we have highlighted earlier, there is no inherent directionality in biological evolution: complexity can decline and traits can decay or become lost within a lineage when such changes provide a selective advantage in a given local environment at a particular time.
As discussed earlier, health policy involves inherent tradeoffs between multiple objectives and competing demands (e.g. elective surgery versus emergency care).
"This pair may have bred early because of the inherent warmth of the city, and mild winter," he said.
Seminal studies of dog behaviour conducted in the 1950s and '60s showed, however, that dogs raised without human contact at an early age retain their inherent instincts and prefer relationships with other dogs over associations with people.
Lead-time is inherent in early detection and creates bias in observational studies of screening efficacy, but its potential to bias effect estimates in risk factor studies is not always recognized.
