Sentence examples for earlier established that from inspiring English sources

It was earlier established that Ogden syndrome, a rare genetic disorder, is caused by a mutation in NAA10 which severely inhibits the catalytic activity of the mutant protein.

We had earlier established that the conformational switching of catalytic residue His114 is responsible for loss of ribonucleolytic activity of certain ANG mutants, and the predictions were correlated with experimental reports.

We have earlier established that secretor (FUT2) gene-dependent glycosphingolipids bind norovirus, in excellent correlation to challenge and outbreak studies, showing the genetic linkage to disease resistance/susceptibility to most, but not all, of the human norovirus strains.

- The role of the cytoskeleton in SOCE regulation has been studied in depth, - and it was early established that STIM1 colocalizes with tubulin and that the treatment of HEK293 cells with nocodazole, which triggers microtubule depolymerization, severly reduces SOCE.

Earlier, we also established that introduction of negative or positive charge at this location resulted in strong alteration of Pi binding, indicating that negative charge within the triangular subdomain was an important determinant of Pi binding.

It's a culture of cooperation and collaboration, and Dave established that mentality early on in our company's development.

The effects observed under baseline glucose conditions are consistent with earlier research establishing that proteasome inhibition results in cardioprotection with ischemia reperfusion [ 17, 32– 32].

Finley said he was trying to throw more fastballs early to establish that pitch.

On that basis, Healthy People 2010 (a DHHS initiative) had earlier established an objective of reducing that percentage to 45% by the year 2010.

Earlier established results showed that for this whole patient group, CT-determined tumoral perfusion was correlated with poorer LC [ 2].

Conclusion This study is one of the few to establish that early weight gain is an independent risk factor for mortality in ICU patients.