Sentence examples for earlier downstream from inspiring English sources

As shown earlier, downstream signaling pathways of receptor tyrosine kinases include not only tyrosine kinase but also serine/threonine kinases.

Similarly, we expect earlier downstream migration because on an annual basis, smolting is advanced by earlier warming.

The IRES localizes to a downstream portion of 5' untranslated region (UTR) and a part of the early downstream coding region of the transcript.

The high level of Hmga2 expression in ES cells, combined with the upregulation of Hmga2 observed in fibroblasts transfected with RNA encoding Nanog suggests that Hmga2 may be an early downstream target of Nanog in fibroblasts during reprogramming.

We found at 48 h that the expression levels of those early downstream genes regulated by RTA were slightly reduced by miR-K12-7 upon chemical induction with 12-O-tetradecanoylphorbol-13-acetate (TPA) and valproic acid (VPA), whereas the expression of the late genes downstream from RTA were not affected (Figure 4A).

A direct association between CTLA4 with CD3ζ leading to its dephosphorylation has been reported, resulting in the inhibition of of the leukocyte-specific protein tyrosine kinase (Lck), a member of the src family of tyrosine kinases responsible for early downstream signaling from the TCR [3].

Notch signalling pathway activation is therefore an early, downstream event in Wnt/β-catenin-induced intestinal tumorigenesis.

The mechanism of PI3Kγ involvement in T-cell response was investigated in a series of studies to monitor the early downstream events of T-cell activation.

We believe that the metabolic cluster in our adolescents signals disease processes early in evolution before other downstream effects.

If we then run this scenario a few more times, the result would be an anabolic or biosynthetic pathway (i.e., 5 ➔ 4 ➔ 3 ➔ 2 ➔ 1 ➔ "nutrient") with the earliest enzyme "downstream" of all the rest.

Twenty-seven of these were novel and expressed in the early embryo downstream of Smad2/3 signalling.