Sentence examples for earlier compound from inspiring English sources

Researchers led by Dr. Yaghi reported last year in the journal Science that an earlier compound, MOF-5, could absorb hydrogen concentrations of 1percentt by weight at room temperature and a pressure 20 times atmospheric pressure.

Novartis protests that this is not a case of evergreening because the new version is significantly superior in that it is 30percentt easier for the body to absorb than the earlier compound.

An earlier compound, MitoDNP (not shown), combines a TPP-targeting group and dinitrophenol, 21 but differs from MitoDNP-SUM (trigger and caged DNP shown) in two critical ways: the dinitrophenol group is not caged, so it would affect all mitochondria regardless of ROS production, and the dinitrophenol unit is permanently attached to the lipophilic cation.

More importantly, the new compound (6b) shows S…arene interaction not shown by any earlier compounds (1, 2 and 3).

These findings suggest that the potent anticonvulsant activities of the earlier compounds were due, in part, to the benzyloxyphenyl motif and provide support for the use of the biaryl-linked pharmacophore in future drug design efforts.

Furthermore, there has been a strong focus on chemistry, e.g. in the study of Lowe and Sayle [13] who looked at the question of how much earlier compounds appear in patents before they can also be found in scientific publications.

But the process and reasoning by which TBB and TBPH were substituted for earlier compounds remains somewhat opaque.

By comparison, this novel compound of this study is fundamentally different from these earlier compounds in both structure and function.

A particular concern with large-scale insecticide application is the pollution it may cause, as most insecticides are harmful to aquatic life (including fish, frogs and other amphibia), while the earlier compounds, such as DDT, also affect terrestrial animals, including birds.

These ASOs contain a phosphorothioate backbone and 2′-MOE (2′-O-methoxy ethyl/phosphorothioate) modifications of the ribose of the first four and last four nucleotides of the ASO, which enhances the affinity for target RNA, increases the plasma stability, and decreases toxicity when compared with earlier compounds.

This chapter focuses on the recent changes in synthetic chemistry practices, shows how these changes are modulated by the target impact on compound properties, and provides guidance on how the pattern of early compound properties can be improved.