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We then tested whether those populations would evolve earlier aging.
The hypothesis presented here draws on an old idea: faster development goes with earlier aging and mortality.
We tested for rejuvenating reproduction in one of the clonal isolates from population 2 that showed earlier aging.
The first scenario corresponds to the evolution of earlier aging by means of antagonistic pleiotropy [ 2], the second by means of mutation accumulation [ 1].
Because the negative effect of this mutation that led to earlier aging in population 2 was confined to late age, and performance at late age was inconsequential for fitness under these conditions, we expected that this mutation would not have an adverse effect on the growth rate.
However, we also observed the spread of a mutation causing earlier aging of mothers whose negative effect was reset in the daughters.
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