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2) Are ErbB receptors expressed during inner ear development?
RA is synthesized in the paraxial mesoderm and influences hindbrain and ear development [44] [46].
It is not known how these or other contaminants might affect ear development in cetaceans.
Inner ear development is highly complex and many distinct signaling pathways regulate it.
Fibroblast growth factors and their receptors have key roles during inner ear development [39], [40].
Therefore, these genes may not function downstream of Slitrk6 during inner ear development.
This unique expression pattern led us to investigate the role of Slitrk6 in inner ear development.
Both IGF-I and its high affinity IGF1R receptor are expressed during inner ear development [6].
These data suggest that RAF kinases also have distinct roles during chicken inner ear development.
POU3F4 is a member of the POU-homedomain transcription factor family with a prominent role in inner ear development.
Insulin-like growth factor-I (IGF-I) provides pivotal cell survival and differentiation signals during inner ear development throughout evolution.
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