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PC carried out the experimental work, participated in the sequence alignment and phylogenetic analysis, and drafted the manuscript.
SET carried out the experimental work, participated in the sequence alignment and statistical analyses and drafted the manuscript.
This award is in recognition of the high quality of work in the history/theory sequence.
Recipient of the Ali Jawad Malik Memorial Theory Honor Award in recognition of high quality of work in the history/theory sequence.
MK carried out the experimental works, participated in the sequence alignment, and drafted the manuscript.
LS carried out the experimental works, participated in the sequence alignment, molecular evolution analysis and drafted the manuscript.
We thank Aurélie Dechaume, Julien Philippe and Sabrina Pereira for their technical work in the Sanger sequencing and the mutation validation.
The peptide dealt with in this work represents the sequence found in the IN-CC Phe185Lys variant (Table 1a).
In addition, evolution works on the sequence level, but proceeds under strong structural and functional constraints.
ADG was responsible for the experimental work and participated in the sequence data analysis.
AD carried out molecular work and participated in the sequence alignment.
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