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The coil emits clicking sounds with each stimulation, and can also stimulate nearby peripheral nerves and muscles.
(H) Average intracellular responses of the neuron in (D) for each stimulation pattern in (E).
Each stimulation site consisted of a 0.9% NaCl solution-soaked sponge square connected to 2 × 3 cm copper mesh.
Finally, we separated fast and slow components of synchronous release by double exponential fits of cumulative latency distributions for each stimulation.
We computed the average of the resulting functions for each stimulation pattern to obtain a template of the average temporal evolution of the response to each stimulus.
The eight different stimulation patterns were presented repeatedly, in random order, to obtain multiple membrane potential responses for each stimulation pattern.
As shown in Supplementary Fig. 10, it also accounts for variance-mean results, both for asynchronous release for each stimulation and for cumulative release.
The membrane potential responses obtained on repeated presentation of each stimulation pattern provided a distribution of the bin averages for each time bin.
Three methods of stimulation were given, and the pain rating score and visual analog scale were measured after each stimulation.
Finally, we address the design of optimal electrode configurations allowing the selective activation of neurons near each stimulation site.
During each stimulation session, after a resting period, subjects were shown images with neutral or negative valence.
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