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The continuous exchange of Pb between compartments follows linear first-order kinetics and is described by different Pb-specific distribution rates, depending on the characteristics of each single compartment.
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The bioaccumulation models consist of a mass balance equation formulated over a single compartment for each vertebrate species (including humans) accounting for major processes of chemical uptake (i.e., respiration, drinking water, and dietary exposures for potential biomagnification) and elimination (e.g., respiration, fecal egestion, urinary excretion, and biotransformation).
We discuss the rationale behind single compartment drug delivery for each of these compartments, and give an overview of examples at different development stages, from the lab bench to phase III clinical trials to clinical practice.
Single compartment pharmacokinetic models were fitted for each person by least squares, using the nlminb function of S-Plus®.
Each gene was then classified as specific (expression only present in a single compartment; validated anchor gene), enriched (expression present in the correct compartment and at least one other compartment; marker gene), ubiquitous (ubiquitous expression in all compartments), not-detected (no detectable expression) or non-specific (expression detected in an unexpected compartment).
For this reason, a simple exponential model was also fitted to each subject's AS data, and compared by analysis of variance (ANOVA) to the single compartment model.
Bifurcations over μ in the single compartment, 2 variable model.
Tibio-femoral premature arthritis can occur from single compartment loading with patellofemoral arthritis in valgus knees.
The CV and EIS experiments were done in a single compartment cell.
Additional file 1: Biodistribution of 213 Bi activity and its daughters for single compartment kinetics.
This indicates that sampling just a single compartment doesn't reveal the entire driving biology.
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