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Distinct transcriptional programs made of interacting networks of TFs each regulating a subset of genes work cooperatively to generate the diversity of cells seen in multicellular organisms.
The final dataset consists of 36 transcription factors, each regulating between 3 and 33 genes, with binding site length ranging between 11 and 48 (see Table 2).
Specifically, we simulated expression levels of 100 TFs, each regulating 21 genes in a simple regulatory network.
The TFs regulating the genes in bicluster B4 have p-values below 1E-15 after correction, each regulating from 50%to95%5% of the genes in bicluster.
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Each regulated profession has developed a College of professional members and public members appointed by the provincial government.
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Because fibrates, niacin, ezetimibe and statins each regulate serum lipids by different mechanisms, combination therapy may offer particularly desirable benefits in patients with combined hyperlipidemia.
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