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For example, cis-regulatory elements active within defined spatial limits during development often use AND logic, in that two different transcription factors, each present in a given spatial domain, must be bound to the cis-regulatory DNA at once in order for transcription to be activated.
Results: Ninety-two percent of patients <10 years old had premature pubarche at presentation, whereas clitoromegaly and acne were each present in only 20% of these younger subjects.
The three classes of core-promoter elements observed in the [-39, -26] region are each present in about 20% of the promoters.
Pain and depression are two of the most prevalent and treatable cancer-related symptoms, each present in at least 20 30% of oncology patients.
Comprised of catalytic and regulatory subunits, each present in multiple forms, AMPK is best described as a family of related enzymes.
It undergoes a Ca2+-myristoyl switch when Ca2+ binds to its two functional EF-hand motifs (EF-hands 2 and 3), each present in one of recoverin's two domains.
The six dyes were each present in the saturating concentrations used above, leading to high impacting TOC (approximately 1580 mg/L).
Although no significant sub-clonal populations of cells were detected within the tumor, there were many rare mutations, each present in only a few cancer cells.
Among the most represented CREs, ACGTABOX, GT1CORE, ARFAT, RYREPEATGMGY2, TATABOX3 and AMYBOX1 are each present in more than 400 up-regulated genes.
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We identified at least three other polymorphisms upstream of the SWS1 and RH2B opsins that also disrupt CRX binding sites--each present in only a single species--but no polymorphisms that interrupt the binding sites of any other candidate transcription factors.
Three novel variants (c.115G→A, c.129_185del57 and c.1074G→A), were each present in one proband and absent from 1000 control chromosomes.
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