The paper examines the evidence from qualitative as well as quantitative studies on each of these pathways.
In each of these pathways, several potential therapeutic targets have been identified and specific inhibitors have already been developed and have shown clinical efficacy.
There are three primary molecular mechanisms of transmitting the signal calmodulin, annexins, and protein kinase C. Each of these pathways intersects and can be cross-regulatory.
The regulatory approach involves, primarily, two major sets of regulations; and the scientific basis for product categorization and the application of each of these pathways is discussed.
For each of these pathways except PFL, we see examples where ethanol production has been engineered with a yield of >90% of the theoretical maximum.
Although SAD has been shown to affect both protein kinases A (PKA) and C (PKC) pathways, the relevance of each of these pathways to its CP induction is unknown.
Activation of each of these pathways has been associated with mRNA turnover control (reviewed in [35]).
Representative genes of each of these pathways are depicted in the right vertical line.
The operation of each of these pathways could give rise to co-localization of bacteria with LC3.
The importance of each of these pathways is supported by a large volume of experimental animal data, and in some cases, clinical trials utilizing specific antagonism of a proposed biochemical mechanism.
While Cho's study identified representatives from important up-regulated pathways, the proteomics methodology employed in our study recognized several more members of each of these pathways – reinforcing their importance in vivo.
