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Exact(53)
Each of these mutations was caused by the activity of endogenous and/or exogenous mutational processes with different strengths.
Although modern sequencing methods have revealed many of the genes that mutate in several different kinds of cancer, uncovering when each of these mutations occurs has been more difficult.
Each of these mutations is known to predispose individuals to Alzheimer's disease.
These findings provide new insights into how each of these mutations in PFN1 might increase its propensity for misfolding and aggregation, leading to its dysfunction.
"Each of these mutations teach us something, and point to a particular gene as a potential target for new and more effective pain medications," he said.
It is expected that each of these mutations will have a ΔΔG of 0. For each protein the average ΔΔG for all of the mutations is recorded as well as the standard deviation.
Similar(7)
For comparison, the same mutations located in other sequence contexts (not preceded by C or followed by G) were used as the control data for each of these mutation types.
For each of these three mutations, a known mutation carrier was used as a positive control in each experiment.
They then constructed 27 genotypes each carrying two of these mutations.
5, 7 Considering that GISTs with KIT exon 11 mutants commonly become imatinib-resistant due to acquisition of secondary mutations in the kinase domain (i.e., V654A, T670I, D816H, D820G, N822K, Y823D, and A829P), 13, 18 we constructed imatinib-resistant double mutants by introducing each of these secondary mutations into the imatinib-sensitive mutant V559D.
As these two genomic alterations are likely to alter the function of the protein and were not found in the control population, it is likely that they are pathogenic mutations, but functional studies will be necessary to determine how each of these MSH6 mutations affects protein function.
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CEO of Professional Science Editing for Scientists @ prosciediting.com