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1When O2 is reduced in four sequential one-electron steps, the intermediates formed are the three major ROS, that is, O2–, H2O2, and HO. 2 3 4 5 Each of these intermediates is a potent oxidizing agent.
This filtration exercise short-listed Raf1, ERK-1/2, MEK-1/2, p38, JNK, CAMKII, Lyn and Akt1 as the target nodes, and all the resulting shortest paths originating from the BCR to each of these intermediates were merged to create a sub-network.
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Now even an infinitely quick transition would, as it sank from consciousness, have to pass through each of these intermediate states.
Thus, each of these intermediate states would only be tolerated in heteroplasmy at low frequencies before reached fixation.
In particular, we assume that a limited number of intermediate traits (or factors, e.g., variations in development or physiology) control the variation in the high-dimensional phenotype, and that each of these intermediate traits is sparse – affecting only a few observed traits.
As for the climbing activity phenotypic classification, flies were termed normal when were undistinguishable from WT, "lack of climbing capacity" when flies stayed permanently at the bottom of the culture vials, "lack of equilibrium when standing" or "slowness" if they displayed each of these intermediate movement coordination phenotypes.
Estimating the direct effect of temperature on asthma emergency department visits is not the objective of this analysis and would require statistical adjustment for each of these intermediate variables, which can result in over-adjustment bias and is inappropriate if the mediator is an effect measure modifier [ 24, 25].
We recreate and experimentally assay each of these evolutionary intermediates.
The ZnO is formed by the dehydration of these intermediates.
I met Abdul*, one of these intermediates, in a small village on the outskirts of the rainforest.
The rearrangements of these intermediates yield Amadori products.
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