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For each methodological item, we defined adequate reporting based on the Cochrane Collaboration Risk of Bias tool [1], the Consolidated Standards of Reporting Trials (CONSORT) [11], the WHO Trial Registration Data Set (http://www.who.int/ictrp/network/trds/en/index.html) and the instructions for registrants provided by registries (Table 1).
All approaches are valid and each methodological decision is associated with strengths and limitations.
Instead, a component approach appraisal allows one to evaluate each methodological aspect.
On each methodological attribute, we gave studies a rating of high, low, or uncertain quality.
For this analysis we did not judge RCTs as methodological 'better' that non-randomized; each methodological design has its unique weakness.
A combined KMIS was calculated for each RCT by adding the scores of each methodological item with a possible KMIS ranging from 0 to 3 [ 1].
Similar(48)
Each of methodological, psychological, and analytical behaviorism has historical foundations.
Most research involves both results expressed statistically (which requires choice of significance threshold and balancing chances of Type I vs. Type II error) and multiple steps each requiring methodological decisions.
Four randomised controlled trials met the inclusion criteria of the review; each had methodological limitations.
The number of studies that reported each key methodological item is provided in Table 3.
The authors' main findings were based on the results of three clinical trials, each with methodological limitations.
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