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For each constraints, there exists one disjunction (in the form A| B, see [Additional file 1]) that emphasizes two distinct regions allowing the existence of the cycles.
Each constraints on a reaction must be defined as a contingency, and each contingency consist of three parts: A target (column B), which identifies the reaction that is affected; a contingency (column C), which defines how the target reaction is affected; and a modifier (column D), which identifies the state causing the effect.
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For each constraint, a production rule is used to detect constraint violation and to initiate database operations that restore consistency.
Algorithms for localization with each constraint based on iteration are proposed.
The order of the approximation for each constraint is automatically adjusted in the optimization process.
Thereby, it enables to analyze the influence of each constraint in the same.
The design for each constraint is confirmed via concrete physical applications with experiments and/or simulations.
Therefore, according to these criteria, each constraint can be classified into one of the six classes: HI_UNAMBIG, HI_NEAR_UNAMBIG, HI_AMBIG, MED_UNAMBIG, MED_AMBIG and LOW_AMBIG.
Considering the compatibility requirements on each constraint point, the relationships between two adjacent spans can be obtained.
The relation between both domains is defined by the projection function and variable mappings according to each constraint of interest.
Each constraint involves some subset of the variables and specifies the allowable combinations of values for that subset.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com