In the end of each period, appetite was assessed by 10-cm visual analog scales immediately before and after a standardized breakfast.
Within each study, appetite assessment scales were administered repeatedly to all patients, which might have desensitized the scales and resulted in a loss of accuracy.
Side effects were consistent with the known adverse-event profile of voriconazole [ 20]: patients reported visual disturbances (21%%); photosensitivity reactions (19 %); blurred vision (12%%); constipation, vomiting, and γ-glutamyl-transferase increase (10%% each); chills, decreased appetite, headache, and insomnia (8 % each); and vertigo, nausea, cholestasis, weight loss, and anorexia (6%% each).
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Only a very small proportion of patients still had mild achiness/fatigue and sore throat (0.78 % each), loss of appetite (approx. 3 %), cough (mild and moderate severity reported in approx. 3 % of the patients) and hoarseness (mild and moderate severity; around 0.4%%).
In addition, nausea was reported by 82% of patients, along with other GI-associated AEs such as diarrhoea, constipation, or decreased appetite, each having a 77% incidence rate.
During the 9-week doublindblindose-confirmationon phase, anxiety and decreased appetite each led to discontinuation in 2.2% of patients in the MPH-LA 60 and 80 mg groups, respectively.
Baseline and post-intervention data were compared as follows: FFS, DVS, and the TMIG Index of Competence within each group using a paired t-test; frequency of intake of each food group, walking and exercise frequency, and self-rated health within each group using the Wilcoxon signed-rank test; and appetite within each group using McNemer's test.
