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Literature information in PubChem can be programmatically accessed through E-Utilities [30] or PUG-REST [31].
The Internet is exerting tremendous pressure on these data providers to create services (often referred to as e-utilities or Web services) that allow users to search and access databases remotely.
The Recent engine needs daily updated PubMed data, which are obtained using NCBI E-utilities [32].
Genbank protein accessions were retrieved using E-utility applications (27).
E-utility allows the extraction of abstracts from PubMed in an automated fashion.
First, Python posts an E-utility URL to NCBI and then retrieves the results of this request, after which it processes the data as required [ 23].
Both sides of the flanking sequences with the length of 500 bp were fetched out by e-utility tools for GC content analysis.
The National Center for Biotechnical Information Entrez Programming Utilities (NCBI E-utility) [ 10] was used to retrieve full PubMed records containing title, authors, abstract, and affiliations based on PubMed Unique Identifier (PMID).
PubMed was integrated through the E-utility Simple Object Access Protocol (SOAP) web service (27), and PubMed Central using the Open Access (OA) REST web services (http://www.ncbi.nlm.nih.gov/pmc/tools/oa-service).
Connections to PubMed were done using the Entrez Programming Utilities (E-Utilities).
In addition, all accessions to the NCBI databases by means of the E-utilities services are performed using the E-utilities own history service.
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