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(e) Conservation relations can be used to replace one ODE for each conserved moiety (e.g. a protein that is not degraded or synthesized).
Many times, in a routin e conservation activity, hidden aspects of books come to the fore.
(e) Conservation score (phastCons) in mESC (p-value = 0.6285, Wilcoxon rank sum test) and in pro-B cells (p-value < 1.7e-4, Wilcoxon rank sum test).
(C, D, E ) Conservation of dinucleotide preferences of the indicated orthologous proteins from fruit fly and human.
(E ) Conservation analysis of the Foxp3 locus finds that downstream and proximal upstream elements are conserved, whereas distal upstream genomic elements encoding the GAGE transcripts are not conserved.
(E ) Conservation of the Treg cell lineage-specific program is statistically significant (y-axis) irrespective of fold-change cutoff (x-axis).
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MP1, mother of P1; fatherather of P1; motherofher of P3; fatherather of P3. e, Evolutionarily conservation of MIR140 in different species; miRNA hairpin sequence is highlighted in gray.
The mean value of the property of interest for the fusion pairs (e.g., conservation of [dis]assembly or reduction of interfaces upon fusion) was compared with the mean value from the randomly selected pairs.
We then examined the evolutionary properties (e.g., conservation profiles and the nature of mutational changes) that distinguish drug-response altering (DR-altering) from drug-response neutral (DR-neutral) nsSNVs.
VEP also enables the incorporation of many other annotations (e.g., conservation scores, is variant position present in HGMD public version, whether variant is cited in PubMed), which will make the screening and filtering steps more manageable.
Combining forces across organizations in traditionally non-interacting sectors (e.g., conservation and economic development) is essential if we are to address the strain of human sewage in our reef systems and their associated human communities.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com