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The dysfunctions that occur after injury and disease are primarily due to neurotransmission damage.
Many studies, based on crossed-section design, have focused on changes in lead-associated neurobehavioral dysfunctions that occur at increased blood lead levels.
Because acute cyclosporine A nephrotoxicity (CSA) is a reversible process in which renal function can recover if the drug administration is stopped at the early stage of the disease, differential diagnosis of this disease with other renal dysfunctions that occur after kidney transplantation is of interest.
Although we are aware of the limitations in the use of a neuroblastoma cell line to recapitulate dysfunctions that occur in neonatal human brain, this experimental model allowed us to dissect in details the molecular events elicited by UCB.
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Second, this study was unable to examine other contributing factors, such as the fibrosis, the remodeling of ion channels, and the autonomic dysfunction that occur as a result of ageing.
Early brain injury includes cell death, cerebral edema, and neuronal dysfunction that occur after SAH.
These convergent pathomorphological and cell biological findings may reflect commonalities in endolysosomal dysfunction that occur in relation to aging and of relevance to AD.
Since both Fus and TDP-43 are RNA-binding proteins, the similarities in dysfunction that occur in response to overexpression of either protein may suggest that dysfunctions in RNA processing are important in the development of disease.
The metabolic shift to aerobic glycolysis and the mitochondrial dysfunction that occur throughout the remodelling event lead to insufficient energy supply, while excitation-contraction coupling impairment and abnormal collagen deposition turn into contractile dysfunction and fibrosis, respectively.
Although the pathological mechanism of IIM remains unclear, recent studies suggest that an interplay between adaptive immune, innate immune, and nonimmune mechanisms may be responsible for the damage and dysfunction that occur in myopathic muscle tissue [ 3].
Based on current knowledge of the effects of IGF2 on synaptogenesis, brain plasticity and memory, we hypothesized that increasing IGF2 expression in the hippocampus may attenuate the memory deficits and synaptic dysfunction that occur in AD.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com