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Mitochondrial dysfunctions have been found to be associated with aging, several degenerative diseases, and cancer., Members of the BCL-2 apoptotic pathway have also been shown to modulate mitochondrial morphology.
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High rates of thyroid dysfunction have been found in patients with bipolar disorder (BD), compared to the general population.
14 Improvements in this hospitalized related cognitive dysfunction have been found 2 to 4 weeks after discharge, 13, 14 whereas one study found further improvements after 1 year.
p53 mutation and dysfunction have been found in over 50% of all types of human cancers, resulting in inactivation, silence, or even dominant-negative inhibition of wild-type p53 [ 4].
Motor dysfunction has been found to be predictive of cognitive dysfunction in Alzheimer's disease and to occur earlier than cognitive impairments.
In glaucomatous patients, a spectrum of mitochondrial abnormalities involving oxidative stress and implying mitochondrial dysfunction has been found [12].
Indeed, callosal dysfunction has been found to be an early phenomenon in ALS [34] and structural involvement of the corpus callosum has been reported in combination with functional impairment [35].
Autonomic nerve dysfunction has been found in patients with SSc [ 18- 22].
Systolic dysfunction has been found to be associated with an increased risk to develop symptomatic systolic HF.
Intestinal barrier dysfunction has been found to play a pathogenic role not only in IBD, but also in IBS [ 1].
Although BDNF has not yet been implicated in early allergic reactions as NGF, its role in allergic airway dysfunction has been found to be important [ 14].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com