The detection of a high number of TUNEL-positive cells confirmed the contribution of non-removed dysfunctional mitochondria to liver pathology in MSD mice.
It needs to be emphasized that simple elevations of ALT are not serious if not followed or accompanied by any liver dysfunctional effects such as hospitalization, inability to work, jaundice, prolonged prothrombin time, secondary kidney failure or brain obtundation.
Lastly, the cross-sectional design of our study did not allow a causal relationship to be determined between dysfunctional SAT and progressive liver disease.
Since the visceral AT depot directly drains into the portal circulation, this may support the notion of crosstalk between dysfunctional AT and the liver.
The mechanism by which CD8+ T cell "priming" in the liver leads to dysfunctional effector cells remains to be determined.
In metabolism, we have identified the TBL1/TBLR1 transcriptional co-factor complex as a key regulator of hepatic lipid homeostasis and fatty liver disease with dysfunctional activities in mono- and multigenic diabetes, in both murine as well as human setting (Kulozik et al, 2011).
Excess adipose tissue, which is a hallmark for an overweight or obese status [ 1, 2], in ectopic locations [like the visceral compartment, liver, muscle] is dysfunctional.
Excess adipose tissue in ectopic locations: especially in the visceral compartment, liver and muscle, is dysfunctional.
TAF4 knockout in post-natal hepatocytes therefore causes severe liver malfunction, hypoglycemia, and dysfunctional bile and lipid transport and metabolism.
