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The BBC is preparing to publish 3,000 pages of evidence received by its Pollard inquiry into the corporation's "dysfunctional" handling of the Jimmy Savile scandal.
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Prolonged mechanical unloading of normal hearts distorts the t-tubules, resulting in dysfunctional Ca2+ handling.
Elevated plasma 1,5-AG in aged, fasted rats may reflect insulin resistance or dysfunctional renal handling of glucose.
Cardiac Ca pumps and transporters are subject to redox-dependent modifications that might contribute to dysfunctional Ca handling in cardiac disease states [ 24].
As a consequence, CaMKII caused site-specific hyperphosphorylation of the SR Ca release channels (at RyR2 Ser-2814), wasch wassociatedted with persistent SR Ca leakage, decreased SR Ca load and dysfunctional Ca handling.
On the other hand, it must also be taken into account that the enhanced recruitment of mitochondria close to ER could be simply the consequence of dysfunctional Ca2+ handling by the store, since mitochondria dynamics is tightly regulated by Ca2+.
Those same political institutions are dysfunctional when it comes to handling just about any issue of substance, suffocating from a political polarization that renders them impotent with respect to the ability to reach compromise.
These studies suggest a dysfunctional sarcoplasmic reticulum (SR), leading to altered intracellular calcium handling in cardiac myocytes.
Phillips, whose relationship with Valentine has at times been dysfunctional, said: "He can handle change.
Washington is now so deeply divided and dysfunctional that many of its traditional mechanisms do not appear to be up to the task of handling a multilayered challenge where many political agendas are at work.
The proposed method can be extended to handle multiple simultaneous dysfunctional molecules.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com