7 Stenhagen et al 8 found three main components that predict falls: reduced mobility (odds ratio [OR] =2.12), heart dysfunction (OR =1.66), and functional impairment (OR =1.38), whereby each component is related to physical fitness.
Indeed, a large proportion of patients with ALS exhibit cognitive impairment, especially executive dysfunction or language impairment.
Corticobasal syndrome (CBS) is a kind of tauopathy with parkinsonism presenting chronic onset of progressive unilateral motor impairment, including subjective weakness, dystonia and parkinsonism, and cognition change, such as apraxia, sensory-motor dysfunction or memory impairment.
No overt motor dysfunction or behavioral impairment was observed.
Mitochondrial dysfunction or the impairment of oxidative phosphorylation results in ROS accumulation (Barros et al. 2004).
Cerebral venous sinus thrombosis (CVT) is a rare, potentially life-threatening disorder that may have vital or morbid consequences, such as motor dysfunction or visual impairment.
No mutations are found to be associated with neuronal dysfunction or intellectual impairment, although 10% of BSCL1 subjects (17 faffected21 affected subjects) tested by Maldergem et al. showed mild or moderate intellectual impairment [ 9].
4 6 8 Studies on medication-related hospital admissions estimate that 21 91% of admissions were potentially preventable. 1 6 9 10 Important patient determinants for ADEs are increasing age, female gender, polypharmacy, non-compliance and comorbidities such as cognitive dysfunction or renal impairment.
Neuropsychiatric symptoms rather than cognitive dysfunction or functional impairment have been suggested to impose the greatest burden on family caregivers, and to predict caregivers' decisions to institutionalize patients with dementia.
