MS causes attacks of neurological dysfunction (loss of vision, difficulty in walking or moving a limb, vertigo, loss of sensation) or progressive dysfunction in these same areas.
Neuronal ceroid lipofuscinoses (NCLs), commonly known as Batten diseases, are a genetically heterogeneous group of lysosomal storage diseases (LSDs) [ 3], characterized by storage of lipofuscin material in lysosome-derived fluorescent storage bodies [ 4, 5] and neuronal demise leading to progressive loss of vision, motor dysfunction and premature death [ 6].
However, vestibular dysfunction in the form of blurring of vision in that a target slips from the fovea makes an eye movement pattern called nystagmus [4].
Incidents of vision loss, extraocular muscle dysfunction (3rd/6th cranial nerve palsy), neuroparalytic keratitis, lacrimal drainage obstruction, and keratitis sicca following these procedures have been reported [ 1, 4- 6].
A generalised dysfunction of cortical areas responsible for vision predicts altered performance for both static and drifting stimulus versions.
In 55%, patients stated the CGA to provide new information on their health status, mainly in the area of sensomotory dysfunction (vision, hearing), cognitive impairment and osteoporosis risk.
Owing to the need of continuous supply of 11- cis-retinal for function and survival, mutations in RPE65 results in dysfunction and degeneration of photoreceptors and thus in loss of vision (Cideciyan et al, 2013).
Restoration of vision due to corneal blindness from corneal endothelial dysfunction can be achieved via a corneal transplantation.
Previous studies have reported that anthocyanins demonstrated ability to protect against a myriad of human diseases such as liver dysfunction, hypertension, vision disorders, microbial infections, and diarrhea [ 15– 17].
