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Other proposed theories are blood brain barrier dysfunction due to small vessel alterations, and consequent chronic diffusion of macromolecules and fluids in the white matter; oxidative stress, endothelial dysfunction and dysfunction of mechanisms of vascular regulation [48].
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Presently, many investigators believe that the dysfunction of microcirculatory mechanisms may be responsible for vestibular symptoms in Meniere's disease.
The dysfunction of apoptotic mechanisms has been pointed as a hallmark of cancer.
The dysfunction of protective mechanisms against atherosclerosis leads to vascular dysfunction and the progressive onset from subclinical lesions to clinical pathological manifestations.
Indeed, while older age at onset is associated with a more rapid disability progression likely due to prevalence of the primary progressive disease course, age-dependent degenerative processes, and dysfunction of repair mechanisms in older subjects early onset MS patients reach disability milestones at a younger age compared to late onset MS cases, even though in a longer time interval [ 26, 75].
To date, db/db have been widely used in studies that have evaluated diabetic complications, including the dysfunction of vasodilatation mechanisms in type 2 diabetes (Pannirselvam et al., 2002; Guo et al. 2005; Belmadani et al. 2008; Miike et al., 2008; Park et al., 2008).
The dysfunction of the mechanism may also lie behind the impairment of the cross-talk between excitatory and inhibitory transport processes in temporal-lobe epilepsy [45], [46].
Dysfunction of these mechanism can result in the development and progression of inflammatory diseases.
The dysfunction of this mechanism would lead to malfunction of microtubule-associated protein translation and to the development of OS.
These suggest that abnormalities of limb morphology might be caused by dysfunction of the mechanism specifying the volume source.
The dysfunction of the mechanism may also lie behind the impairment of the cross-talk between excitatory and inhibitory transport processes in temporal lobe epilepsy [ 79].
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