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By contrast, plasma lactate levels were not significantly associated with non-pulmonary organ dysfunction (data not shown), although clinically measured levels were only available in a subset of patients (n = 74).
No abnormal chromosome fusion events were observed in TANK1−/− mice, consistent with absence of telomere dysfunction (data not shown).
Overall, our results show that oxidative stress increased with age, (appearing to accelerate more rapidly after mid life), in association with reduced antioxidant defence mechanisms, and mitochondrial dysfunction; data consistent with the predictions of the free-radical theory of aging.
In addition, the levels of miRNAs such as miR-137, miR-663, miR-1231, miR-1246, and miR-1287, which are not targeting IRS-1 3'UTR, were not affected by mitochondrial dysfunction (data not shown).
However, neither of our patients had concomitant ear and eye structural abnormalities or dysfunction (data not shown).
When organ dysfunction data were missing (for instance, serum bilirubin), scores were imputed using an algorithm (Table 1) based on methods from previous sepsis studies [ 5, 8].
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Data fields abstracted included the etiology and complications of cirrhosis, preoperative (admission, 48 hours, day of transplant, if applicable) hematologic, biochemical and physiological/organ-dysfunction data (requirement for vasopressors, mechanical ventilation, renal replacement therapy (RRT)), donor information, and outcomes after LT (see Table 1).
Among strategies to reverse BM dysfunction, our data showing no correlation between HbA1c and mobilization suggest that glucose control might not be effective, whereas experimental data indicate that boosting the antioxidative defense is a suitable strategy to prevent BM alterations (4).
Although cystatin C can detect early kidney dysfunction, limited data are available on the association between cystatin C and HF.
The makers of two new pills for erectile dysfunction presented data today that they hope will help them take on Pfizer's Viagra.
Though there is evidence to implicate that the mitochondrion may play an important role in the development of postresuscitation myocardial dysfunction, limited data are available regarding the ultrastructural alterations of the mitochondria, mitochondrial energy-producing ability, and their relationship to postresuscitation myocardial dysfunction.
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