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> Based on the reaction rates, we derived an ODE model describing the interaction dynamics of module I and module II proteins and the signal transduction via the regulation of c-di-GMP levels in the cell (Eq. 1).
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The design and dynamics of the module are highly optimized for both catalysis and fidelity in the construction of complex, biologically active natural products.
In the allowed families of networks, we distinguish those with and without feedback on the basis of whether the internal dynamics of the module has a role on determining their input output behaviors or not.
Both these results are easily understood in terms of the dynamics of the module.
Understanding the dynamics of these modules will shed light on the processes that occur in cancer cells resulting from errors in cell cycle regulation.
The dynamics of these modules between normal and disease states further suggest a potential molecular model of dilated cardiomyopathy.
In contrast, our work focuses on studying conditional and time-dependent behaviours or sequential dynamics of network modules, which are functionally enriched on specific biological processes [ 13].
The dynamics of genetic modules are represented as a linear-state space equation and the observability of linear time-varying systems is defined by imposing sparse constraints in Kalman filters.
miRNAs can have a profound effect on the dynamics of regulatory modules, both by control of amplitude, namely by affecting the level of gene expression, as well as by control or alteration of frequency, namely by interference with the temporal sequence of gene production or delivery.
The model is formed by a dynamical reservoir reproducing the dynamics of a cortical module interacting with the selection mechanism within the basal ganglia which is implemented similarly to what done in Gurney et al.
Reconstruction allowed us to examine how different combinations of mutations alter the dynamics of the polarization module.
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