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Understanding a disease process at the pathway level (i.e., PD and systems dynamics components of the source-to-outcome continuum) is in itself not sufficient to define reliable and informative mechanistic models because of great model sensitivity to uncertain inputs.
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Reviewer #1 This manuscript presents a comprehensive analysis of the dynamics of components of the Clathrin-mediated endocytosis machinery in yeast Saccharomyces cerevisiae.
Further research might help to identify and explore the factors influencing engagement with the summative and formative assessment feedback, and how, or if, these affect the dynamics of the components of the framework.
The temporal dynamics of these components of the model are specified by four differential equations: (1) (2) (3) (4) The model is provided in SBML format as additional file 1 and in the Biomodels database: http://www.ebi.ac.uk/biomodels-main, model number 1006280000. Figure 1 shows the interactions that correspond to each of the mathematical terms in the above equations.
The Land-model uses a standard cooperative binding equation which has a Hill curve as its steady state solution to represent troponin binding, where the calcium half activation of maximal steady state tension generation is length-dependent, combined with a modified version of the crossbridge dynamics component from the model developed by Rice et al.[ 19], which uses a 4-state Markov model.
Our primary concern in building a reliable model was to express the assumptions in quantitative terms in order to isolate in silico the contribution to the dynamics of the main components of the model.
The aim of this work was to characterize the dynamics of the key components of the type I IFN-beta signaling pathway in macrophage RAW 264.7 cells.
Bulelzai and Dubbeldam 20 developed a simplified model for the dynamics of the main components of the atherosclerotic plaque: macrophages, monocytes, foam cell, and oxidized LDL.
The items reflecting the influence of the unknown flow disturbances in the receiver dynamics are taken as the components of the "lumped disturbances" together with the items which have no linear correlation with the virtual control variables.
Considering a reduced center-of-mass model for bipedal walking, by utilizing the Capture Point as a system coordinate one can separate the stable and unstable components of the dynamics.
Blocking purinergic signaling allowed us to uncover other components of the dynamics of neurogenesis induction.
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