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We modeled dynamically concentration-dependent responses of pathway effectors (inhibitors, activators, drug combinations) to cyclic nucleotide signaling as well as to downstream signaling events and verified resulting model predictions by experimental data.
Independence of stationary point with respect to initial dynamic variable values confirms a unique stationary point in the phase space of dynamically varying concentrations of the model network.
Both the cases of constant and dynamically varying initiator concentration were treated for a wide range of reactor operating conditions.
This behavior further confirms that the fabricated sensor in this study can be used in the environment with dynamically changing O2 concentration.
While most cells dynamically regulate the concentration of the second messenger Ca2+ in the cytosol and various organelles, transport proteins rarely discriminate strongly between Ca, Sr, and Ba.
The volume expansion and mass gain upon hydration show marked variations due to the presence of a significant fraction of permanent voids, revealed by dynamically averaged water concentration maps.
Accordingly, the change of the total receptor concentration dynamically changes the concentration-effect relationship of rHuEPO.
Thus, activation of TRPC3 at elevated expression levels significantly enhanced NCX currents in this voltage-clamp protocol, indicating that TRPC3 may dynamically affect ion concentration at the exchanger.
Metabolic enzymes control cellular metabolite concentrations dynamically in response to changing environmental and intracellular conditions.
Dynamically varying contaminant concentrations pose a challenge in the design and operation of biofilters for air pollution control.
CoastMab predicts TP concentrations dynamically and, in addition, it predicts Secchi depths and cyanobacteria from empirical cross-systems regressions.
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