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Understanding network topology through embracing the global dynamical regulation of genes in an active state space rather than traditional one-gene one trait approne-gene oneatraithe rapproachdrug development process.
We have found that the miRNA and the TF usually have dynamical regulation programs at different stages during mouse lung development.
Regardless of these progresses in research on palmitoylation of AMPARs, there are many mechanisms on dynamical regulation of between palmitoylation and depalmitoylation remain elusive.
The dynamical regulation due to mRNA stability is found to be an important aspect of the genome-wide coordination of the long-period yeast metabolic cycle.
Furthermore, the presented work provides a detailed insight into the interactions between the multiple DGC- and PDE-type enzymes and the role of c-di-GMP in dynamical regulation of cellular decisions.
Indeed the most important problem in cell modelization is the continuous modification in cellular protein content and in molecular interactions due to the dynamical regulation of genes expression and protein transcription.
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Moreover, dynamical regulations of the genes by such perturbations might control neural differentiation.
To decipher the dynamic regulation mechanism of a transcriptional-regulatory system, a sequential logic model (SLM) is used to demonstrate the existence of dynamical logical mapping between trans-activation and temporal mRNA expression profiles.
Simulation results are also shown using practical example of Insulin-Glucose regulation dynamical model to illustrate the effectiveness of the proposed method.
A thorough analysis of these three models shed new light onto the dynamical constraints of SC regulation in the SAM: none of the models was able to correctly predict CLV3 and WUS over-expression phenotypes and SC homeostasis under changing growth conditions at the same time.
Different dynamical patterns of Msn2 regulation in turn can lead to qualitatively different expression outputs of downstream targets [ 59].
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