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Although several models have been proposed to account for the fascinating, dynamic, regulated enrichment and loss of Hh effectors in the ciliary membrane, we still know few mechanistic details.
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High nPCC indicates that the neighbors of the protein are highly co-regulated and that the protein is probably located within a dynamically regulated module (dynamic module) whose protein constituents are highly co-expressed.
During aging in C. elegans, Wnt signaling pathway was identified as another truly aging-dependent pathway with dynamic regulation, which was significantly up-regulated from L4 to D6 and down-regulated from D6 to D15.
In our study, this pathway was also identified as one of truly aging-dependent pathways with dynamic regulation, which was significantly up-regulated from L4 to D6 and down-regulated from D6 to D15 (Table 1).
Within each of these superfamilies, a significant and roughly equivalent number of genes were either up-regulated or down-regulated by NaCl at the transcript level, suggesting dynamic regulation of glycosylation in response to stress.
"If you go back and look at our history, we were most successful when we had that balance between an effective, vigorous government and a dynamic, appropriately regulated market," Mrs. Clinton said.
Cytosolic complexes such as ESCRTs and their associated proteins are involved in these highly dynamic and regulated processes.
However, it remains unclear how this sensory epithelium responds to specific pathogenic challenges in a dynamic and regulated manner.
Adult hippocampal neurogenesis is a highly dynamic and regulated process that evolves slowly over several weeks (Zhao et al., 2008).
The host cellular machinery is controlled by a highly complex, dynamic and regulated modular protein interaction network [ 15].
Although the functions of only a minority have been described, their dynamic and regulated expression suggests that many more may be functional.
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