Both microtubules and actin filaments have been demonstrated to play important roles in cell motility, and their dynamic rearrangement during cell motility is regulated by diverse cytoskeleton-associated proteins (Waterman-Storer and Salmon, 1999; Olson and Sahai, 2009).
While the sample was drying, they monitored the movement of PS particles in real time using an optical microscope, which revealed dynamic rearrangement of particles toward to the center region of the circular patterns.
The method provides a basis for adaptation to other types of polyadenylated RNAs, enabling the comprehensive identification of bound proteins/RNAs, and the investigation of dynamic rearrangement of mRNPs imposed by cellular or environmental cues.
Fluorescence signals (blips) arising from single functional IP3Rs are almost immotile (diffusion coefficient <0.003 μm2 s−1), as are puff sites over prolonged periods, suggesting that the architecture of this signaling system is stable and not subject to rapid, dynamic rearrangement.
Cell polarization and migration require dynamic rearrangement of the actin and microtubule cytoskeletons via intracellular signaling pathways involving Rho family GTPases [10] [12].
Dynamic rearrangement of F-actin proceeds via a series of signaling events involving kinases, phosphatases, adopter molecules and a host of actin binding proteins [39].
