Wu, Y., Dissing-Olesen, L., MacVicar, B. A. & Stevens, B. Microglia: dynamic mediators of synapse development and plasticity.
The high interspecies conservation observed for these molecular subunits assembled in a dynamic complex (Mediator complex) involved in signalling pathways, with prominent regulatory functions of gene expression, noteworthy implied in response to stress, explains and supports sufficiently their early evolutionary appearance and preservation in eukaryotes.
Phosphorylation presumably prevents stress response gene transcription under non-stress conditions, supporting the idea that a dynamic and differential Mediator subunit phosphorylation contributes to gene regulation in eukaryotic cells (Miller et al. 2012).
Both X-ray crystallography and EM studies corroborate that the overall structural organization of human and yeast Mediator is dynamic.
This illustrates potential for RACK1 to be selectively translocated to the nucleus in response to cellular signals and suggests that RACK1 will be found within other transcriptional complexes as a critical mediator of dynamic cytoplasmic to nuclear signaling responses for environmental cues that control neuronal plasticity, epithelial cells migration or differentiation, and immune responses.
Cdc42, Rac1 and RhoA have been well established as mediators of dynamic reorganization of the actin cytoskeleton, microtubule dynamics and junction maintenance in epithelial cells [19], [20].
Finally, dynamic processes were partial mediators of the relationship between composition/structure and mechanical function, and results suggested that mediation is likely shared between multiple dynamic processes.
Moreover, cART, CD4 + T-cell count, HIV viral load, and CVD risk mediators are dynamic variables which change over time.
The response to radiation is dynamic and involves several mediators of inflammation and fibrosis that are produced by macrophages, epithelial cells and fibroblasts.
