The main focus is on methods alleviating the effects of resource churn, where their performance is largely dynamic, their lifespan is short, nodes are mobile and heterogeneous, and information on their status is partial and typically out of date.
This interpretation is further supported by the observations that loss of daf-7 and tph-1 reduced the dynamic range of lifespan responses, and lowered the accuracy of food level representation.
The hypermethylation may potentially cause long-term problems of intestinal functions in preterm neonates although the effects could also be more temporary, as DNA methylation is highly dynamic throughout the lifespan of mammals [ 3, 34, 35].
The short lifespan and dynamic nature of well drilling operations makes this a challenge.
This revealed widespread and dynamic metabolome reorganization throughout lifespan.
First, loss of both tph-1 and daf-7 reduced the dynamic range of the lifespan response to food by ∼60%.
Also: "Thus, the observed gradual, dynamic metabolome remodeling throughout lifespan, including both increases and decreases in metabolite signals, implied a role of predetermined, genetically-defined aging".
The observed gradual, dynamic metabolome remodeling throughout lifespan, including both increases and decreases in metabolite signals, implied a role of predetermined, programmatic (but not necessarily programmed), genetically-defined aging (Pletcher et al., 2002; Somel et al., 2010; de Magalhaes, 2012).
Further, this 52.6% overlap in differential methylation is considerably smaller than the 80% overlap observed for the gene expression profiles (manuscript 000141R1 accepted in AGING), suggesting that changes in DNA methylation may be more dynamic across the cellular lifespan.
Studies have also reported changes in brain topological organization over the course of development and in senescence [26] [30], implying that the brain undergoes dynamic functional reorganization across the lifespan.
