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The means and the standard deviations of the log10-transformed results obtained during the study trials were 2.76 ± 0.08 E. coli/100 mL and 2.47 ± 0.09 intestinal enterococci/100 mL (n = 38) compared with 2.77 ± 0.18 E. coli/100 mL and 2.49 ± 0.30 intestinal enterococci/100 mL (n = 43) obtained in the round-robin trial.
During the study trials, the latency became shorter as trials proceeded, within a day as well as across days, in both iv/iv and iv/+ mice, resulting in a significant main effect of Day (F2,40 = 41.62, p<0.001) and Trial (F4,80 = 9.99, p<0.001).
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The third memory question asked about the extent to which participants' memory involved thinking about their internal feelings or reactions during the study trial.
If no next of kin can be contacted during the screening for the study, trial inclusion is conducted as an emergency procedure by the ICU physician, in compliance with French law.
To ensure animal welfare was not compromised during the study, all trials were observed by a researcher who could intervene and separate subjects if necessary during a trial.
Subjects in Trials 1 and 3 could not consume ethanol during the study; subjects in Trial 2 were instructed to continue their usual drinking pattern during the study (an average of 1-3 drinks/day).
15 There were no drug-related adverse reactions found during the study in either trial.
Overall, 471 trials were conducted during the study period of which 77 trials were excluded: 33 were methodology trials that entailed no study drugs being administered, six were cancelled before drugs were administered, 30 were initiated on paper records before the computerized data collection was installed, and eight were phase I trials conducted with patients.
For each month, patients were identified as SGA initiators if they (a) had not received a previous intentional SGA trial during the study period, and (b) received an intentional trial that month for any of the five study SGAs.
The low dropout rate and spread of attendance noted (from zero to six visits during the study period in both trial arms) also strengthens the study findings.
The median overall and progression-free survival for patients (N = 129) who participated in one of three clinical trials during the study period was 13.5 months (95% CI, 11.2 15.8) and 5.6 months (95% CI, 4.9 6.0), respectively.
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CEO of Professional Science Editing for Scientists @ prosciediting.com