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Severe neutropenia and stomatitis developed during the second course of DCF therapy.
It is unclear whether the lack of systemic immunomodulatory medications influenced the onset of uveitis during the second course of rifabutin since patients have developed rifabutin uveitis while iatrogenically immunosuppressed after transplantation [9].
"Ooh, this is strange," declared one of the children during the second course, as she eyed a mound of caviar which she described as "disgusting".
Two patients received reduced CDDP during the second course at each level.
Blood cultures obtained during the second course of vancomycin were negative.
N-desmethyltamoxifen levels were lower than tamoxifen during the first course (2 microM) but increased to equal tamoxifen levels during the second course.
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Thus, students are required to enroll in the first course (301A) during Autumn Quarter and the second course (301B) during Winter Quarter.
Symptoms generally started during the first or the second course and seemed initially mild to moderate.
However, the fever reoccurred during the second day of the second course.
The optimal dose is typically the Maximum Tolerated Dose (MTD) defined by the occurrence of severe toxic side effects during the first course of treatment.
For pharmacokinetic analysis, plasma sampling was performed during the first course and assayed using a validated high-performance liquid chromatographic assay with mass spectrometric detection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com