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On the other hand, some inverse changes in mitochondrial abundance and function are observed during the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).
Ji J, Ng SH, Sharma V, Neculai D, Hussein S, Sam M et al. Elevated coding mutation rate during the reprogramming of human somatic cells into induced pluripotent stem cells.
Here we used single-cell RNA sequencing to overcome this limitation and analysed global transcriptome changes at early stages during the reprogramming of mouse fibroblasts into induced cardiomyocytes (iCMs 1,2,3,4.
To investigate the relationship between PpCSP1 and other factors involved in the reprogramming, we analysed transcript levels of WOX13-like genes11 in nPpCSP1-Citirine-3′-UTR and nPpCSP1-Citrine-nosT lines with 5′-DGE during the reprogramming of cut leaves.
Interestingly, CASP3 and another pro-apoptotic factor CASP8 are activated during the reprogramming of iPSCs.
MET occurs during organ development and also at an early stage during the reprogramming of fibroblasts [57,66,67].
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This has provided a surprisingly detailed understanding of the fundamental roles that these enzymes play in controlling gene expression, cell fate decisions during development, and the reprogramming of chromatin states.
A disturbance in the reprogramming of macrophages during disease can be associated with an inadequate alteration of a specific phenotype.
The molecular mechanisms which origin the reprogramming of meristem during floral induction are key to acquiring floral identity [ 35, 36].
The reprogramming of telomeres during iPSC generation provides formal evidence that telomeric chromatin structure is defined by cell-type-specific epigenetic programmes that can be reversed by reprogramming.
If unique signatures are considered, both 21nt and 24 nt smRNA diversity increased from stage A to B, suggesting a higher smRNA complexity during the reprogramming phase of grain development.
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