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Similar to hNAP1 (see Fig.  1e), SET enhanced activated transcription during the PIC assembly step of initiation (Fig.  3c).

Collectively, these data demonstrate that hNAP1 is not a prototypical transcriptional activator, but rather functions on chromatin templates during the PIC assembly step to further stimulate activated transcription.

Model describing conformational rearrangements of the PIC during scanning and start codon recognition.

One of the proteins that make up the small ribosomal subunit (called Rps5 in budding yeast) is located near the channel where the mRNA molecule exits the PIC during scanning, and is also thought to be involved in translation initiation.

Results and interpretation The PIC received 50 claims for compensation during the 8-year study period.

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The PIC ranged from 0.022−0.746 (mean = 0.354), with 18 of the markers moderately informative (PIC > 0.40) and one marker highly informative (PIC > 0.70; Pob1170.70

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