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It may be that the presence of maternal antibodies and foetal haemoglobin during the first two courses of IPTi result in lower parasite densities in asymptomatic children and therefore in better clearance, even with imperfect or even failing anti-malarial drugs.
These events were observed during the first two courses of chemotherapy.
Planned visits were scheduled for Days 1 and 14 during the first two courses, thereafter only on Day 1 of each course.
from baseline was 21.0 (±10.6) and 14.9 (±11.7) ms observed 2 h post-administration during the first two courses for schedule A (300 mg) and schedule B (150 mg), respectively.
During protocol treatment, clinical findings and laboratory data were evaluated every 2 weeks during the first two courses of treatment and then on the starting day of each subsequent course.
In the clinical trial, G-CSF was administered chronically, before and during the first two courses of chemotherapy, while it was given as bolus injection in the mouse studies discussed here, a difference that might explain the modest effects on leukaemias of this treatment modality.
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The level of CEP gradually increased during the first three courses of chemotherapy and declined during the later treatment courses.
Two of these patients also had progression of their ovarian cancer during the first four courses of therapy.
Serum CA 125 regression after cytoreductive surgery and during the first three courses of chemotherapy was studied in 60 ovarian cancer patients and compared to known prognostic factors.
The levels of CEC and V-CEC significantly decreased as the number of chemotherapy courses progressed (P = 0.02), but the CEP levels significantly increased during the first three courses of chemotherapy (P = 0.02) and then declined during later treatment courses.
Treatment compliance was high, as the mean individual dose of sagopilone during the first six courses was 15.4 mg m−2 in the 16 mg m−2 group and 12.0 mg m−2 in the 12 mg m−2 group.
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