Sentence examples for during the earliest steps from inspiring English sources

The defects in endocardial behavior in tal1-deficient embryos originate during the earliest steps of endocardial morphogenesis: tal1-deficient endocardial cells fail to generate a cohesive monolayer at the midline and instead pack tightly together into a multi-layered aggregate.

In addition, how organisms such as Drosophila and vertebrates, which establish DNA methylation patterns during the earliest steps of embryogenesis, differentially methylate genes during later stages of development remains unclear [4].

It has been shown that ERM proteins are normally recruited during the earliest steps of bleb retraction in normal cells, and Ezrin is required to retract short-lived blebs induced by the alteration of cortical tension in mammalian cells [26], [30], [31].

The vitellogenic period is also characterized by intense deposition of RNA and proteins, as well as lipids, vitamins and hormones, which are necessary during the earliest steps of embryonic development [ 41].

In this study, mouse embryonal carcinoma cells (line P19) have been employed to address the question of how such molecular diversification develops during the earliest steps of differentiation that take place in the early embryo.

During the earliest steps of embryonic development there are dramatic changes in transcriptional dynamics.

Hence, social influence and diffusion of responsibility are fundamental processes underlying the bystander effect during the early steps of the decision-making process.

EMT is therefore thought to play a fundamental role during the early steps of invasion and metastasis of carcinoma cells.

Results show that it is necessary to take into account the dynamical constraints under fault operation, during the early steps of the system design process.

Ref. [78] explores a methodology to control and monitor frequency during the early steps of power system restoration, and uses generator modeling to calculate the single machine equivalent of the power system based on phasor measurement unit (PMU) measurements.

This is done by verifying the intensive time-consuming part of the circuit in the emulator and the non-synthesizable part as well as the part of the circuit that needs intensive redesign process during the early steps of the design phase in the simulator.