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It is hypothesized that during the delay conditioning paradigm coupling the PF signal with a delayed CF signal can increase the efficiency of the PF-mediated VGCC pathway.
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Then we show the learning properties of the long-time scale component using examples of the delay conditioning paradigm.
Classical heart rate conditioning was performed using the delay conditioning paradigm.
Because the stimulus remains on during delay conditioning, the stimulus may serve to focus attention, which differentiates the Stimulus-on state from other states.
Trace conditioning engages additional areas of the neocortex than the simpler delay conditioning, in particular areas that maintain working memory processes [ 80].
For example, blockage of electrotonic coupling in the inferior olive results in impaired learning-dependent timing of locomotion steps during classical delay conditioning (Van Der Giessen et al. 2008).
CRs were made in the same time period as during delay conditioning (Fig. 1A, row 3, block8 vs Fig. 1B, row 3, block 1).
Another study employed a continuous pairing design during trace conditioning and a 50% pairing rate during delay conditioning [27].
Figure 1B summarizes the anatomical pathways known to support the classical delay conditioning.
In our study, even those children who gave few CRs during delay conditioning showed consolidation and generalisation at the start of trace conditioning indicating normal cerebellar function.
A few children showed very poor learning during delay conditioning but all immediately showed early responses in the second session.
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